https://www.youtube.com/watch?v=uJMCNJP2ipI
So it seems inevitable that Upper Deck will do a Deadpool & Wolverine set as the new film should fall under their Marvel/Disney license. Sure, it's won't come out until 2 years after the movie, but I think it will definitely be a major release for them.
Hugh Jackman and Ryan Reynolds have both signed for X-Men sets in the past, so it's possible Upper Deck will get one or both to sign. Unfortunately, they'd be sticker autos, but I'm sure that means we'd see both actors in a bunch of future Marvel Cinematic sets as well as UD will hoard those stickers for years and slowly trickle them out.
If I was Upper Deck, after doing a Deadpool & Wolverine set, I'd do a Deadpool Retrospective set of all 3 films, if Marvel would allow it. An X-Men Retrospective Set would also be a possibility. Same with Fantastic Four. Legally, there should be no issues. It's just whether Marvel wants new merchandising produced from the Fox films they own.
It looks like Deadpool will likely have a bunch of X-Men cameos and possibly even Dr. Doom (since they seem to be setting up Battle World), so the potential signer list could be huge.